![]() ![]() Results: The two genes CDKN2A + PLAU were closely related to lymph node metastasis of oral squamous cell carcinoma. The area under the curve (AUC) ultimately determined the diagnostic value of the prediction model. The model was validated with 95 OSCC samples in this study. ![]() In this retrospective study, the gene expression profile and clinicopathological parameters of 112 OSCC patients were combined to construct the best prediction model for lymph node metastasis of OSCC. Methods: Based on a previous study of related genes in OSCC, the mRNA expression of candidate genes was evaluated by real-time PCR in OSCC specimens. ![]() This study aimed to construct and validate a preoperative prediction model for lymph node metastasis and guide personalized neck management based on the gene expression profile and clinicopathological parameters of OSCC. However, there is no proper method for predicting lymph node metastasis. Objective: Lymph node metastasis is the most important factor influencing the prognosis of oral squamous cell carcinoma (OSCC) patients.
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